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ZS Pharma time to first recurrence of hyperkalaemia
Potassium binder versus placebo for chronic <t> hyperkalaemia </t> in people with chronic kidney disease (CKD)
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Potassium binder versus placebo for chronic  hyperkalaemia  in people with chronic kidney disease (CKD)

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: Potassium binder versus placebo for chronic hyperkalaemia in people with chronic kidney disease (CKD)

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Comparison, Control, Derivative Assay

Calcium polystyrene sulphonate (CPS) versus sodium polystyrene sulphonate (SPS) for chronic  hyperkalaemia  in people with chronic kidney disease (CKD)

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: Calcium polystyrene sulphonate (CPS) versus sodium polystyrene sulphonate (SPS) for chronic hyperkalaemia in people with chronic kidney disease (CKD)

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Comparison, Control

High versus with low‐dose potassium binder for chronic  hyperkalaemia  in people with chronic kidney disease (CKD)

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: High versus with low‐dose potassium binder for chronic hyperkalaemia in people with chronic kidney disease (CKD)

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Comparison, Control

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet:

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Transplantation Assay

Ash 2015

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: Ash 2015

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Control, Sequencing, Selection, Blocking Assay

HARMONIZE 2014

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: HARMONIZE 2014

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Pregnancy Test (hCG) Assay, Sterility, Calcium Carbonate, Generated, Control, Medications, Clinical Proteomics, Activity Assay, Sequencing, Selection

Kashihara 2018

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: Kashihara 2018

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Control, Medications, Sequencing, Selection

Nakayama 2018

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: Nakayama 2018

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Control, Sequencing, Selection, Clinical Proteomics

Nasir 2014

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: Nasir 2014

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Blocking Assay, Control, Medications, Sequencing, Selection

Packham 2015

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: Packham 2015

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Control, Calcium Carbonate, Generated, Medications, Sequencing, Selection

Wang 2018a

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: Wang 2018a

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Transplantation Assay, Control, Sequencing, Selection, Concentration Assay

NCT03781089

Journal: The Cochrane Database of Systematic Reviews

Article Title: Potassium binders for chronic hyperkalaemia in people with chronic kidney disease

doi: 10.1002/14651858.CD013165.pub2

Figure Lengend Snippet: NCT03781089

Article Snippet: Serum potassium was measured at 1, 2, and 4 hours after first dose on day 1, as well as just prior to and 1 hour after first dose on day 2 of the open‐label phase (primary study outcome) Biochemistry: serum calcium; serum magnesium; serum phosphate; SCr; BUN; serum bicarbonate; serum aldosterone; plasma renin activity Urine analysis (including urinary sodium excretion) and urine culture Proportion of patients who were normokalaemic at end of study Cumulative days patients remained normokalaemic Time to first recurrence of hyperkalaemia (potassium ≥ 5.1 mEq/L) Electrocardiography Vital signs Body weight Heart rate Notes Funding: The study was sponsored and funded by ZS Pharma.

Techniques: Concentration Assay, Control, Medications